The Mexican Method!
The "Mexican method" to autograft MS patients uses Cyclophosamide (chemotherapy) that kills T cells, and Rituxumab, a monoclonal antibody works on the protein CD20, which is primarily found on the surface of immune system B cells. When it binds to this protein it triggers cell death.
The method is started on an outpatient basis and ends on a outpatient basis for most patients.We will be living in a fully furnished apartment and transported to the Clinic when having treatments. Only a small fraction of people require hospital admission sometime during the treatment process.(Hospital Angeles de Puebla) is used.
Conditioning Regimen
1. Day -11 Cyclophosamide
2. Day-10 Cyclophosamide
3. Day -9 to -2 Filgrastim every 12 hours sq(this help stimulate your stem cells).
4. Day -4 First stem cell collection/harvest
5. Day -3 Second(if necessary)stem cell collection
6. Day -2 Third(uncommonly necessary) stem cell collection
Cyclophosamide, MESNA(to decrease the risk of bleeding in the bladder)
7. Day -1 Cyclophosamide, (MESNA)
8. Day 0 Transplant of the collected stem cells apheresis CD34+ cells (stemmies B-day).
9. Day +30 or before Rituxumab infusion
Available Medical staff 24/7.
Total stay is 4 weeks!!
Recommended maintenance therapy of Rituxumab IV following HSCT: every 2 months for 12 months.
Outpatient Service:
1. Patient MUST have a carer for assisting patient in preparing meals, personal care & assistance.(Dave is my carer).
2. Transportation to/from airport.
3. Transportation between apartments and Clinica Ruiz.
4. Fully furnished apartment to accommodate 2 people. Includes 2 bedrooms, kitchen, microwave, crockpot, telephone, TV, internet service, washer/dryer.
5. Daily apartment cleaning and surfaces sanitizing during neutropenia.
6. Pre-packaged processed food suitable for consumption during neutropenia(7-10 days)
7.Available wheelchair, walker, shower chair, and other assistive devices.
8. Available on-site treatment facility English/Spanish translator.
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